Alpha-terpinyl acetate: A natural monoterpenoid from Elettaria cardamomum as multi-target directed ligand in Alzheimer’s disease
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چکیده
منابع مشابه
Molecular Investigations of Protriptyline as a Multi-Target Directed Ligand in Alzheimer's Disease
Alzheimer's disease (AD) is a complex neurodegenerative disorder involving multiple cellular and molecular processes. The discovery of drug molecules capable of targeting multiple factors involved in AD pathogenesis would greatly facilitate in improving therapeutic strategies. The repositioning of existing non-toxic drugs could dramatically reduce the time and costs involved in developmental an...
متن کاملTranscriptome profiling of Elettaria cardamomum (L.) Maton (small cardamom)
Elettaria cardamomum (L.) Maton, known as 'queen of spices, is a perennial herbaceous monocot of the family Zingiberaceae, native to southern India. Cardamom is an economically valuable spice crop and used widely in culinary and medicinal purposes. In the present study, using Ion Proton RNA sequencing technology, we performed transcriptome sequencing and de novo transcriptome assembly of a wild...
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The development of drugs with different pharmacological properties appears to be an innovative therapeutic approach for Alzheimer's disease. In this article, we describe a simple structural modification of AP2238, a first dual function lead, in particular the introduction of the catechol moiety performed in order to search for multi-target ligands. The new compound AP2469 retains anti-acetylcho...
متن کاملAntiulcerogenic activity of Elettaria cardamomum Maton. and Amomum subulatum Roxb. seeds
Small cardamom known as 'Heel Khurd’ (fruits of Elettaria cardamomum Maton.) and large cardamom 'Heel Kalan’ (fruits of Amomum subulatum Roxb.) are used in Unani System of Medicine to treat gastrointestinal disorders. These seeds are used as stomachic (Muqavvi-e-Meda), desiccant (Mujaffif), resolvent (Muhallil), digestive (Hazim) carminative (Kasir-eRiyah), etc. Their essential oils and petrole...
متن کاملData on identification of conserved and novel miRNAs in Elettaria cardamomum
Elettaria cardamomum (L.) Maton, or small cardamom referred as 'queen of spices', is a perennial herbaceous rhizomatous monocot of the family Zingiberaceae. Cardamom seeds and fruits are the economically significant parts and effectively used as a traditional medicine, food additive and flavoring agent. In the present study, using Ion Proton next generation sequencing technology we performed th...
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ژورنال
عنوان ژورنال: Journal of Functional Foods
سال: 2020
ISSN: 1756-4646
DOI: 10.1016/j.jff.2020.103892